r/Kava • u/LurkyMcLurkface123 • 2h ago
Interaction Regarding the FAQ - Kava and APAP (Tylenol)
I’m thinking trying Kava as a way to wind down and reduce hyper vigilance in the evenings and weekends. I found the FAQ really helpful in providing information regarding the safety profile of Kava.
The last study mentioned, however, depicted measurable impact on liver function when Kava was combined with APAP, a drug notorious for causing significant liver damage at high doses.
The dosages used in the study were fairly extreme: up to 500mg of kava per kg of body weight combined with I believe 800mg of APAP per kg.
My intention would be to use one or two servings of Kava in the evenings or weekends. I don’t consume any alcohol, but I do take 1000mg of APAP once or twice a week for headache. I weigh approximately 90 kilos.
Is there any data available, anecdotal or literature, regarding in vivo toxicity when combining kava and APAP? Does anyone have direct experience? I don’t plan on over indulging in either substance and I’m generally healthy, but any reassurance would be appreciated.
Thanks!