r/TTC_PCOS • • 27d ago

Monthly Medication Thread

1 Upvotes

This thread is the place to post any questions or information pertaining to a medicated cycle including Letrozole, Clomid, IUI, injectables, Progesterone, and anything else used to induce ovulation or support a cycle.

Please be mindful in your responses - if someone does not solicit a success response, DO NOT share a pregnancy outcome.


r/TTC_PCOS • • 3d ago

Success Sunday - Week of October 25, 2026

3 Upvotes

Get a BFP? Post about it here! In your post please include if you had regular cycles on your own, any medications you are taking, supplements, and how long you were trying. Feel free to post links to your chart, photos of sticks, etc. Please feel free to graduate on over to our sister subs and congratulations! Success stories posts are now weekly! Please click here to search for previous threads.


r/TTC_PCOS • • 6h ago

Other First time entering the 2 week wait feeling like I have some sort of chance

3 Upvotes

Our ttc journey, like a lot of people in this sub, has not been easy. When i got my mirena coil removed over 2 years ago i was bleeding/spotting everyday. I was told this was due to to annovulation and was strongly encouraged to lose weight. Im on metformin. My bmi has went from 42.6 to 30.9 so I still have a long way to go with weight loss. However, after medication for 6 months my spotting has greatly improved. I only stopped medication 5 weeks ago so its still early days but I went back to Ovulation testing again and for the first time ever in 2 years got a peak. Apparently today is Ovulation day and yesterday we did the no pants dance. I know ideally we should have been doing that more frequently during the build up but I had 2 days of high tests completely out of the blue after my readings being below 0.1 for days. I feel like for the first time ever we atleast have a chance. But if it doesnt happen, I hope this month will atleast help me predict my cycles/Ovulation. Thinking of everyone going through this journey!


r/TTC_PCOS • • 1h ago

Seeking Success Clomid success stories

• Upvotes

Just finished up my 3rd round of clomid, just want to hear some positive stories anyone might have.
My first round was 50mg - no ovulation
Second round 100mg - ovulated but didn’t conceive
Third round- unsure yet but my ovulation tests are almost peak. I’m hoping this round will be it for me. 🤞🏻


r/TTC_PCOS • • 10h ago

Seeking Success Looking for some positive IVF with PCOS success stories! 💕

3 Upvotes

Hi everyone! 💗 I’m looking for some positive stories from anyone who has PCOS and has been through IVF, particularly those who have had success with a frozen embryo transfer (FET).

A little bit about my journey:
✨ I have PCOS and insulin resistance.
✨ I also have type 1 diabetes.
✨ My partner and I had our egg retrieval earlier this year. We collected 30 eggs, 27 were mature, 10 fertilised, and we ended up with four day-5/6 4BB blastocysts.
✨ I’m currently on Buserelin for down-regulation before a fully medicated FET, hopefully in November.
I’m trying to stay positive, but after everything that comes with PCOS and IVF, I think I could really do with hearing some hopeful stories. 🥹💗

I’d especially love to hear from anyone who:

💕 Has PCOS
💕 Has type 1 diabetes or insulin resistance.
💕 Has had success with a 4BB embryo.
💕 Has had success with their first FET.
💕 Has undergone down-regulation before a frozen transfer.

I know everyone’s journey is different, and I’m not expecting any guarantees. I’d just love to hear your experiences and give myself a little hope going into our first transfer. 🤞🏼✨

Thank you so much to anyone who takes the time to share. Sending lots of love and baby dust to everyone going through this journey! 🌈💗


r/TTC_PCOS • • 5h ago

Advice Needed Anyone had confirmed ovulation on Letrozole, negative tests but still no period?

1 Upvotes

​

Hi everyone,

I'm 37, have PCOS and I'm on my second round of Letrozole 5mg.

I had a scan on 9th October which showed two mature follicles measuring 19.5mm and 19.1mm. My progesterone blood test on 19th October came back at 57, so the clinic confirmed I'd ovulated.

I'm not 100% sure when I ovulated, but I'm thinking somewhere between 11th and 15th October.

I've been testing since the 24th and they've all been negative. This morning I used a Clearblue and thought it was negative after 3 minutes, so I went back to sleep. When I woke up nearly 2 hours later, there was a faint blue line. I know I can't count that as positive because it was outside the reading time.

I did another test today and that was negative too.

The strange thing is I have absolutely no period symptoms. Normally I get sore breasts and brown spotting before my period, but I've had nothing at all.

My clinic has told me to test again tomorrow morning.

Has anyone been in a similar situation? Did you eventually get a positive or did your period arrive later?

Also, if you had confirmed ovulation but no pregnancy and no period, what did your fertility clinic do next? Did they do a blood hCG test or give you medication to bring on a period?

I'd love to hear everyone's experiences, even if the outcome wasn't pregnancy. Just trying to understand what might happen next. ❤️


r/TTC_PCOS • • 6h ago

Seeking Success Going to start letrozole

0 Upvotes

Hi all. It's going to be a long post.

I'm 25F. I have been on a rollercoaster of doctor visits for the last 3 years. Now I've found a doctor who actually listens to me and understands my concerns.

She prescribed hbc for 2 months to artificially regulate my cycle or hormones or something like that, along with some supplements to improve egg health. And she asked me to visit her on CD2 of the period that arrives after the 2nd month on HBC

Im on CD 2 today and she prescribed let*ozole 5mg right off the start from CD 2-6. She has ordered a HSG for me on CD8 and is starting ovulation monitoring from CD 9 through scans. This is the plan so far. She also asked me to lose a bunch of weight. I'm 75kgs, 157cm. She said I need to be around 60kgs. I'm soooooooo tired of doctors asking me to lose weight. Im genuinely tired.

After the consult today, i got super scared of doing HSG since I heard so many people tell that it is super painful in this platform. I am very much scared of the pain but I can understand that my doctor wants to rule out all other obstacles that might stand in the way of my conception. I was also sceptical that she prescribed 5 mg straight away without starting with 2.5 mg.

But I feel like she made that choice after looking at my history and my period cycle. I want to hear some positive notes about success with let**zole. And maybe some assurance about HSG as well. Because the whole doctors visit today and all the over thinking got to me and I started to feel like maybe I don't want to conceive at all.

I feel like this is taking away the joy of trying to get pregnant and I don't know if I will be happy even if I am pregnant at this point because of all the medicines I am going to be taking to get there

This is not to shame other people but to learn from them how they accepted and enjoyed their pregnancy journey despite all the surrounding negativity and struggles and plenty of comments from people very close to you.

I am so tired of starving myself and trying to lose weight and I have been eating healthy diets the past 3 months because apparently good food will improve egg quality.

Please let me know your thoughts


r/TTC_PCOS • • 14h ago

Advice Needed Does anyone have any tips for 100% anovulatory pcos? I don't think I've ever ovulated in my life without meds

3 Upvotes

Hi! I'm sure this has been asked before but I'm looking for advice for my situation. We are doing medicated cycles and are taking a break for a few months if this cycle is unsuccessful and looking for advice for what to do while we take a break. I'd give anything to be able to try naturally while we take our break from treatments. At this point, I've just about given up on being able to have a cycle at all but wanted to just try one last time to see if anyone has advice!

I've been TTC for almost a year and got diagnosed with pcos this year but have had symptoms & problems for 15 years. I'm currently on my 3rd medicated cycle, which has been successful with making me ovulate but no success with pregnancy yet. Without meds, it's like I don't have a functioning reproductive system at all. I have an extremely high AMH of 28 ng/ml. Ovaries blocked with follicles. I don't have periods, ever. I don't ovulate, ever. I didn't appear to ovulate in my life until my medicated cycles this year.

I'm currently taking inositol 4000mg daily. I was on it for about 5 months without any luck regarding my periods or ovulation. I know they say give it 6 months but I began medicated cycles at 6 months, so idk if it worked. And then all of my metabolic markers are normal. My hormonal bloodwork is normal outside of my AMH and my LH is 1.8x higher than my FSH. I strength train and eat as well as I can. So I guess I'm just not really sure what else to do. Nothing I seem to do makes any difference.

TIA!


r/TTC_PCOS • • 10h ago

Advice Needed Clomid, no ovulation yet and a cyst on my scan — what usually happens next?

1 Upvotes

I’m looking for experiences from anyone who has been in a similar situation while taking Clomid.
I don’t get periods or ovulate on my own, so I’m doing a round of Clomid under the care of a fertility specialist.

I had a scan after my first round of Clomid, but unfortunately, it looks like I haven’t ovulated yet. My scan showed a larger follicle (around 21–23 mm) on one ovary, which my specialist has referred to as a cyst now.

What has your experience been after getting a cyst on clomid?


r/TTC_PCOS • • 11h ago

Ovulation, LH strips and letrozole

1 Upvotes

Im currently on first round of letrozole from cd3 - cd7.

I had an ultrasound scan on cd 9 that confirmed one folicle of 28mm size. At the moment im on cd 10 and LH test are completely negative (and were negative 2 days ago). My doctor told me that ovulation is approaching and that on letrozole it usually happens on cd 12 or cd 13. Im having another ultrasound scan on tuesday to confirm ovulation. Anyways, Im now confused because of negative tests.

I also know that 28mm is kind of a large size for F on cd9, but I hope it still works out.

Has anyone had similar situation? How did it turn out?


r/TTC_PCOS • • 18h ago

Seeking Success progesterone

3 Upvotes

hello!

my husband and i have been TTC for a year. 3 months ago i got my progesterone drawn at 7dpo and it was 2.3. cycle after that i started letrozole 2.5 and got a progesterone drawn at 7dpo. it was 4.6. this month we did 5 of letrozole and progesterone suppositories starting at 2dpo. got my labs drawn at 7dpo and it was 23.2! went to see my fertility doctor yesterday and she was very pleased with my levels. she thinks we could be pregnant now. i don’t wanna get my hopes up but anyone else have a similar experience?

PS im 12dpo today:)


r/TTC_PCOS • • 1d ago

Seeking Success Letrozole success stories please

7 Upvotes

As the title says: please comment your successes with Letrozole!

28F with lean PCOS TTC for 6 months. Did a paid referral to a fertility clinic and now have NHS funded treatment. Waiting for my Provera and Letrozole prescription to come through. My first cycle will be monitored with timed intercourse (husband semen analysis was normal - just slightly high viscosity).

I've gone down a rabbit hole of looking at success rates and spiralled into thinking there's a massive chance it doesn't work and after 6 cycles I'm going to be put on an IVF waiting list.

I take 4000mg inositol (in the correct ratio) alongside fish oil, magnesium glycinate and prenatal supplements. Also doing carb pairing, 8k steps daily and post-meal walks. This foundation hasn't helped me ovulate regularly but hoping it will help letrozole success


r/TTC_PCOS • • 17h ago

Advice Needed Am I Ovulating? Low Progesterone but Rising Oura Temperatures

0 Upvotes

I’m 33F with PCOS and currently TTC. My last two cycles have been regular (29 days).
I’m currently on CD22. I had my progesterone tested on CD21, and it came back at just **1.3 nmol/L**, which seems very low for the luteal phase.
However, my Oura temperatures have been rising for the past two days (+0.1°C and +0.2°C), and today Oura flagged “Major Signs of Strain” despite me feeling completely normal.
I’m confused about whether I’ve already ovulated, might be ovulating late, or haven’t ovulated at all.
**Has anyone experienced low progesterone around CD21 but confirmed ovulation later? Can temperatures rise even if ovulation hasn’t happened?**
Would really appreciate hearing your experiences, especially from anyone with PCOS!


r/TTC_PCOS • • 20h ago

Advice Needed Two month wait for RE appointment, glp1?

1 Upvotes

Hi everyone, first I want to say how grateful I am to have found this community, it’s given me so much reassurance and comfort over the past few months.

My situation: 33 years old, married, ttc and newly diagnosed with pcos in July. Obgyn said it’s probably been masked by BC for years. My AMH over is 16, A1c is 5.3, horrible cystic acne, unexplained weight gain, fatigue, the works.

Last month we did our first round of letrozole 2.5 with timed intercourse (unsuccessful) and my dr recommended we go straight to RE because of low motility results (3%) in husbands SA.

My questions: I’ve been taking inositol, working with a nutritionist and incorporating more strength training since July and have not lost any weight or seen any improvements in my cycle or ovulation. Is it worth going on a glp1 for a couple of months while I wait for my RE appointment in mid-December? Any other recommendations? The uncertainty is so hard to manage.


r/TTC_PCOS • • 23h ago

LH CONFUSION

1 Upvotes

Using 5mg letrozole day 2-6, I had a scan on day 13 I had 2 mature follicles and told ovulation was imminent.

Day 14 in the evening my LH test was positive I took that as my surge, day 15 really strong ovulation pain, EWCM and BD both those days.

The problem is my LH tests seem to always linger around 0.7 even after my peak and yesterday day 17 I got another positive test, I’m 95% sure I DID ovulate on day 15 but now I feel like I’m unsure and should be trying again incase I miss it. However I’m taking progesterone suppositories and also feel so tired in general from the whole process.

Any advice on if I keep trying or trust the first surge?

Also I am not tracking BBT - I should but I forget more often than not and need to buy a new thermometer


r/TTC_PCOS • • 1d ago

How did mounjaro affect your periods?

2 Upvotes

I normally have a 35-40 day cycle but recently had a 29 day cycle for the first time.


r/TTC_PCOS • • 1d ago

Vent Why do I torture myself!

3 Upvotes

Had an IUI so now I’m in the waiting game…
However I decided to torture myself and take a test 5-6 days before my expected period (9 days after IUI). It was negative, but it could definitely have been too early to test.

Idk why I did it. I went into it thinking fuck it, don’t be disappointed if it’s negative, but maybe it’ll be positive. Of course I was disappointed when it was negative.


r/TTC_PCOS • • 1d ago

Seeking Success Only PCOS girls how was your fertility treatment ?

6 Upvotes

I am 29 F. TTC for 3 years now I am still struggling to figure out the health care system and how to manage my PCOS.

i had my first failed IUI this month does anyone had a similar experience please guide me.


r/TTC_PCOS • • 1d ago

Advice Needed What to do if ovulating regularly but not getting pregnant?!

3 Upvotes

I’m 29f and my husband 26m have been ttc for 1.5 years. Through my oura ring and Mira I’ve been able to confirm ovulation pretty much every month but one anovulatory cycle. My cycle is typically 30-32 days with ovulation around CD19. My longest cycle this past year has been 36 days and my shortest 29 days when I did strictly carnivore.

I have an ultrasound schedule for next week as I was given an official pmos diagnosis last year for painful periods (which I still have), slightly high prolactin 27.4 ng/mL, and struggle to lose weight (5’8” & 178lbs). My TSH was 2.29 (but hasn’t been checked in a year).

We did an at home sperm analysis and my husband’s result were in a normal range although on the lower side.

After my ultrasound I’m going to get my labs done with Function. I’m considering metformin and other medications but it seems most women are trying to induce ovulation whereas I ovulate regularly but it is a bit delayed. Could I still benefit from medications? Anyone who is similar to me had success and what did you do?


r/TTC_PCOS • • 1d ago

Advice Needed TTC journey — looking for advice and others who can relate ❤️

1 Upvotes

Hi everyone! I’m 24 and my fiancé and I have been trying to conceive for about 5–6 months. I’ve always struggled with irregular periods, although they were more consistent for a few years before becoming irregular again.
My last period was April 16–20, and I haven’t had any bleeding since. It’s now been almost 6 months without a period, and I’m getting frustrated and worried because having regular cycles and the chance to get pregnant is really important to me.
I’ve been tracking ovulation with LH strips and have had some tests get darker, so I thought I might have caught a surge in August, but I never confirmed ovulation. I’ve also taken multiple pregnancy tests, but they’ve been negative.
I had bloodwork done with my OB/GYN. My TSH was 3.87, FSH was 6.1, and my 17-OH progesterone was 52. I was told my labs looked good overall, although I’m still trying to understand what everything means. I haven’t been able to get the recommended ultrasound yet because of the cost.
I don’t have a PCOS diagnosis, and a previous ovarian ultrasound didn’t raise any concerns that I was told about. I’ve wondered whether stress could be contributing to my irregular cycles, but I don’t know for sure.
I’ve been taking a prenatal, CoQ10, and myo-inositol at different points in this journey, but I haven’t been consistent with them lately.
I’m mainly looking for advice from anyone who has experienced long gaps without a period while TTC, especially if you eventually figured out what was causing it or were able to get your cycles back. What testing or questions should I bring up with my OB/GYN? Has anyone experienced something similar?
I know everyone’s journey is different, but it would be nice to hear from people who understand how frustrating this can be. ❤️


r/TTC_PCOS • • 1d ago

Seeking Success 2 dominant follicles and a positive OPK

2 Upvotes

24 yo Fem with PCOS. After THREE years of trying and taking countless of supplements and medications, I finally have two dominant follicles and a positive OPK after taking 7.5 mg Letrozole and Estradiol.

I’m wondering if anyone has a similar story to mine? How many cycles did it take you to get pregnant? Send your words of encouragement and all the baby dust!


r/TTC_PCOS • • 1d ago

Advice Needed Naturopath appointment

1 Upvotes

Hi, I have my first naturopath appointment tomorrow. For background I’m 31 with lean PCOS and have been TTC for 10 months but because of my irregular cycles have only been able to TTC about 5 times. Im on my second letrozole cycle this time 7.5mg, last cycle was on 2.5 mg and never ovulated :(

I’m really trying to figure out my root cause, which I think is likely stress, inflammation, high androgen driven because of some facial hair. If you were me, heading into this appointment, what labs would you advocate for getting tested? Open to any advice on what to ask for during this appointment? Thanks!


r/TTC_PCOS • • 1d ago

Abnormal HSG

1 Upvotes

I had my HSG today and my fallopian tubes looked good and open but they said there was a dull spot on my lower uterus/top of cervix that was abnormal. They said this could represent a fibroid/polyp/adhesion. I’m wondering if anyone had this and if you had any issues conceiving or maintaining a pregnancy?


r/TTC_PCOS • • 2d ago

Naturally ovulating

2 Upvotes

I just had my first medicated cycle and it failed. I am totally bummed about it, but I am one day closer to my success. I was about to ovulate on letrozole. However due to financial reason I can’t do my second round until December. I am currently on my period and wondering if I could ovulate naturally on my own.

Has anyone ever experienced this before? Had a failed cycle then naturally ovulated?


r/TTC_PCOS • • 2d ago

Advice Needed Variation in AFC - what’s considered normal?

2 Upvotes

In July I had a total AFC of 34 (20, 14) leading to my PCOS diagnosis. Since then my total AFC at baseline scan has been slowly declining or varying:
July: 34
August:25
September: 27
October: 17
(None of these times have I had as high as 20 on one ovary)
My AMH in June was 15.8pmol (2.2 ng)

Is this kind of variation common with PCOS? Could this be a sign or declining reserve? Is this normal body variation? If I end up doing IVF I’m worried it’s on a steady decline